Recombinant attenuated clostridium organisms and vaccine

Details Recombinant attenuated clostridium organisms and vaccine Recombinant attenuated clostridium organisms and vaccine

A - Human Necessities

61

K

A61K 39/08 (2006.01) A61K 35/74 (2006.01)

Patent

CA 2649426

The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His68. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.

La présente invention concerne des organismes atténués de Clostridium perfringens exprimant une toxine alpha sensiblement non toxique. La toxine alpha exprimée est une mutéine de délétion à laquelle il manque, par rapport à la toxine alpha de la toxine alpha mature de la souche 13 de Clostridium perfringens, au moins neuf résidus d'acides aminés consécutifs y compris His68. Ladite invention concerne également des organismes atténués codant pour les mutéines ainsi que l'utilisation de tels organismes atténués comme vaccins.

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