Recombinant avian influenza vaccine and uses thereof

Details Recombinant avian influenza vaccine and uses thereof Recombinant avian influenza vaccine and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2744454

The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines.

La présente invention concerne les vaccins contre la grippe, en particulier les vaccins contre la grippe aviaire. Le vaccin peut être un vaccin à virus fractionné fondé sur lhémagglutinine de la grippe. Lhémagglutinine peut sexprimer dans des végétaux tels que la lentille deau. Linvention concerne également des vecteurs recombinants codant et exprimant des antigènes de la grippe, des épitopes ou des immunogènes qui peuvent être utilisés pour protéger les animaux contre la grippe. Linvention concerne également une posologie de vaccination compatible avec la stratégie DIVA, comprenant un schéma de primo-vaccination/rappel à laide du vecteur et de vaccins à virus fractionné.

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