Recombinant baculoviruses containing insect cellular promoter

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/86 (2006.01) A01N 57/16 (2006.01) A01N 63/00 (2006.01) C07K 14/46 (2006.01) C07K 14/70 (2006.01) C12N 7/01 (2006.01) C12N 9/16 (2006.01) C12N 15/11 (2006.01) C12N 15/866 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2138988

2138988 9400585 PCTABS00030 A method of expressing heterologous proteins in insect cells using recombinant baculovirus comprising a structural gene for a heterologous protein functionally attached to an insect cellular promoter, wherein the insect cellular promoter is a promoter which is not naturally functionally attached to the structural gene, such that the heterologous protein is expressed in the insect cells having the recombinant baculovirus. The heterologous protein includes proteins capable of incapacitating the insect. The invention is also directed towards expression cassettes comprising an insect cellular promoter capable of directing the expression of a heterologous protein in tissues containing the expression cassette, recombinant expression cassettes containing heterologous proteins, transplacement fragments and vectors containing recombinant expression cassettes, and recombinant baculoviruses derived therefrom.

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