C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 39/04 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/33 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2589204
Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express an endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains.
L'invention concerne des souches de Mycobacterium capables de déclencher une réaction immunitaire à lymphocytes T CD8+ restreints par le complexe majeur d'histocompatibilité de classe 1. Ces souches de Mycobacterium sont modifiées génétiquement pour exprimer une protéine de l'endosome active à un pH neutre (telle que la perfringolysine O, par exemple), afin de permettre à Mycobacterium de s'échapper des endosomes dans le cytoplasme de la cellule. L'invention concerne également des préparations vaccinales contenant ces souches de Mycobacterium.
Hone David Michael
Sadoff Jerald C.
Sun Ronggai
Aeras Global Tb Vaccine Foundation
Macrae & Co.
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