Recombinant blood-coagulation proteases

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/64 (2006.01) C07K 1/113 (2006.01) C07K 14/48 (2006.01) C07K 14/745 (2006.01) C12N 9/50 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01)

Patent

CA 2257118

The invention relates to a non-glycosylated protein with enzymatic and serin protease activity, the zymogenous form thereof comprising the following domains of a protease of the factor IX family: (a) a catalytic domain, N- terminal bonded with (b) a zymogenous activation domain, N terminal bonded with (c) a EGF1 and/or EGF2 domain. Said protein can be used in a same way as the natural serine proteases of the factor IX family.

L'invention concerne une protéine à activité enzymatique non glycosylée, présentant une activité de sérine protéase et dont la forme zymogène est constituée par les domaines suivants d'une protéase de la famille du facteur IX: a) domaine catalytique, lié à l'extrémité N-terminale avec b) un domaine d'activation de la forme zymogène, lié à l'extrémité N-terminale avec c) un domaine EGF1 et/ou EGF2. Cette protéine peut être utilisée de façon analogue aux sérine protéases naturelles de la famille du facteur IX.

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