Recombinant bovine thrombin

Details Recombinant bovine thrombin Recombinant bovine thrombin

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 1/18 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12N 9/74 (2006.01) C12N 15/00 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2467509

Methods are disclosed for producing recombinant thrombin from precursor molecules that do not require activation by Factor Xa. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. Methods for purification of the thrombin precursors are also described. Thrombin precursors produced from transformed or transfected host cells are auto- activated or secreted in an activated form.

L'invention concerne des procédés permettant d'élaborer de la thrombine de recombinaison à partir de molécules précurseurs, sans activation par le facteur Xa. La protéine est élaborée à partir de cellules hôtes transformées ou transfectées par le biais d'une ou plusieurs constructions d'ADN contenant l'information nécessaire pour orienter l'expression des précurseurs de thrombine. L'invention concerne également des procédés permettant de purifier des précurseurs de thrombine. Les précurseurs de thrombine élaborés à partir de cellules hôtes transformées ou transfectées sont auto-activés ou sécrétés sous forme inactivée.

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