Recombinant canine adenovirus (cav) containing exogenous dna

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 39/235 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C07K 14/13 (2006.01) C12N 7/01 (2006.01) C12N 15/10 (2006.01) C12N 15/861 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2259460

Disclosed and claimed are recombinant adenoviruses, methods of making them, uses for them (including in immunological, immunogenic, vaccine or therapeutic compositions, or, as a vector for cloning, replicating or expressing DNA and methods of using the compositions and vector), expression products from them, and uses for the expression products. More particularly, disclosed and claimed are recombinant canine adenoviruses (CAV) and methods of making them, uses for them, expression products from them, and uses for the expression products, including recombinant CAV2 viruses. Additionally, disclosed and claimed are truncated promoters, expression cassettes containing the promoters, and recombinant viruses and plasmids containing the promoters or expression cassettes.

Adénovirus de recombinaison, procédés de production de ces derniers, utilisations de ces derniers (notamment dans des compositions immunologiques, immunogéniques, vaccinales ou thérapeutiques ou bien en tant que vecteur pour le clonage, la réplication ou l'expression d'ADN et procédés d'utilisation des compositions et du vecteur), produits d'expression de ces derniers et utilisations desdits produits d'expression. D'une manière plus spécifique on décrit dans cette invention des adénovirus canins de recombinaison (ACR) et des procédés de production et d'utilisation de ces derniers, des produits d'expression issus de ces derniers ainsi que leurs utilisations, y compris les virus ACR2 de recombinaison. On décrit également des promoteurs tronqués, des cassettes d'expression contenant les promoteurs et des virus et des plasmides de recombinaison contenant les promoteurs ou les cassettes d'expression.

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