Recombinant canine herpesviruses

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/38 (2006.01) A61K 31/70 (2006.01) A61K 39/245 (2006.01) A61K 48/00 (2006.01) C07K 14/03 (2006.01) C07K 16/08 (2006.01) C07K 16/40 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 9/00 (2006.01) C12N 15/52 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2243662

The present invention includes novel recombinant canine herpesvirus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including therapeutic compositions to protect animals from disease. The present invention also relates to novel isolated CHV nucleic acid molecules, to CHV proteins encoded by such nucleic acid molecules, and to antibodies raised against such CHV proteins as well as to the use of such CHV nucleic acid molecules, proteins and antibodies as therapeutic compositions to protect an animal from CHV. The present invention also includes constructs comprising CHV nucleic acid molecules that include heterologous nucleic acid molecules, to recombinant vectors including such constructs, and to the use of such constructs and vectors in the production of recombinant CHV and recombinant CHV genomes.

On décrit un nouvel herpèsvirus canin recombiné (CHV) et de nouveaux génomes de CHV recombiné, et notamment des CHV et génomes de CHV contenant des molécules d'acide nucléique hétérologues. On décrit aussi des utilisations variées de ces génomes et virus, y compris pour les compositions thérapeutiques destinées à protéger des animaux contre la maladie. On décrit en outre de nouvelles molécules isolées d'acide nucléique de CHV, des protéines de CHV codées par ces molécules d'acide nucléique, et des anticorps développés contre ces protéines de CHV, ainsi que l'utilisation de ces molécules d'acide nucléique de CHV, des protéines et des anticorps entrant dans des compositions thérapeutiques destinées à protéger un animal du CHV. On décrit enfin des produits d'assemblage comprenant des molécules d'acide nucléique de CHV qui incluent des molécules d'acide nucléique hétérologues, des vecteurs recombinés comprenant ces produits d'assemblage, et l'utilisation de ces produits d'assemblage et vecteurs pour produire des CHV ou génomes de CHV recombinés.

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