C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/56 (2006.01) A61K 38/47 (2006.01) A61K 48/00 (2006.01) C07K 19/00 (2006.01) C12N 9/24 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01)
Patent
CA 2526720
Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used it as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
L'invention concerne des molécules support recombinées présentant des séquences d'acides aminés obtenues à partir d'enzymes thermostables ainsi que des méthodes d'utilisation pour l'expression, la récupération et d'administration de séquences étrangères (peptides et polypeptides) produites dans différents systèmes (bactéries, levures, ADN, cultures de cellules telles que de mammifères, végétaux, cultures de cellules d'insectes, protoplastes et plantes entières) in vitro ou in vivo. Les molécules support recombinées utilisant des séquences obtenues à partir de lichenase B (Lic B) ont également été obtenus et utilisées en tant que partie de protéine support pour exprimer, récupérer et administrer une variété de polypeptides cibles à étudier.
Mett Vadim
Musiychuk Konstantin
Yusibov Vidadi
Fraunhofer Usa Inc.
Robic
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