C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A01K 67/027 (2006.01) C07K 1/00 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C07K 16/26 (2006.01) C07K 16/46 (2006.01) C12N 9/00 (2006.01) C12N 9/50 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12N 15/57 (2006.01)
Patent
CA 2501581
The present invention provides a recombinant catalytic polypeptide for cleaving a target protein, the nucleic acid encoding the recombinant catalytic polypeptide, a cell hosting the nucleic acid encoding the recombinant catalytic polypeptide, and a non-human transgenic mammal that is capable of producing a heterologous antibody with proteolytic activity. The invention also provides methods of cleaving a target protein using the recombinant catalytic polypeptides both in vitro and in vivo. The invention further provides a library of recombinant catalytic polypeptides with altered enzymatic activity and a method to alter enzymatic activity of the recombinant catalytic polypeptides.
La présente invention concerne un polypeptide catalytique recombinant destiné à cliver une protéine cible; un acide nucléique codant le polypeptide catalytique recombinant; une cellule renfermant l'acide nucléique codant le polypeptide catalytique recombinant; et un mammifère trangénique non humain pouvant produire un anticorps hétérologue présentant une activité protéolytique. L'invention concerne également des méthodes de clivage d'une protéine cible au moyen des polypeptides catalytiques recombinants de l'invention ausi bien in vitro que in vivo. L'invention concerne en outre une bibliothèque de polypeptides catalytiques recombinants présentant une activité enzymatique modifiée, et une méthode permettant de modifier l'activité enzymatique des polypeptides catalytiques recombinants.
Larrick James W.
Smider Vaughn
Fetherstonhaugh & Co.
Integrigen Inc.
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