Recombinant cell producing 2-hydroxyisobutyric acid

Details Recombinant cell producing 2-hydroxyisobutyric acid Recombinant cell producing 2-hydroxyisobutyric acid

C - Chemistry, Metallurgy

12

P

C12P 7/42 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2729476

The invention relates to a cell which has been genetically modified so as to be capable of producing more 2- hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A as intermediate and 3-hydroxybutyryl-coenzyme A as precursor.

L'invention porte sur une cellule qui a subi une modification génétique de façon à pouvoir former, par comparaison avec son type sauvage, une quantité plus importante de polyhydroxyalcanoates contenant de l'acide 2-hydroxyisobutyrique ou des motifs monomères d'acide 2-hydroxyisobutyrique, caractérisée par le fait que la formation des polyhydroxyalcanoates contenant de l'acide 2-hydroxyisobutyrique ou des motifs monomères d'acide 2-hydroxyisobutyrique a lieu par l'intermédiaire d'acétoacétyl-coenzyme A en tant que produit intermédiaire et de 3-hydroxybutyryl-coenzyme A en tant que précurseur.

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