Recombinant cladosporium herbarum allergens

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/35 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/37 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170356

The invention relates to recombinant DNA molecules that code for polypeptides that have the antigenicity of the allergens Clah53, Clah47, Clah22 and Clah11 or for peptides that have at least one epitope of these allergens. These molecules are characterized in that they have nucleic acid sequences that homologously match the sequences, 1, 3-5, 7- 9, 12-14 as well as 16 and 17, or with segments of these sequences, or have nucleic acid sequences that hybridize with the indicated nucleic acid sequences under stringent conditions.

L'invention se rapporte à des molécules d'ADN recombinées codant pour des polypeptides qui possèdent l'antigénicité des allergènes Clah53, Clah47, Clah22 et Clah11 ou pour des peptides présentant au moins un épitope de ces allergènes. Ces molécules sont caractérisées en ce qu'elles présentent des séquences d'acide nucléique qui concordent, de façon homologue, avec les séquences 1, 3-5, 7-9, 12-14 et 16 et 17, ou avec des domaines partiels de ces séquences, ou des séquences d'acide nucléique hybridées avec les séquences d'acide nucléique précitées dans des conditions sévères.

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