C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/08 (2006.01) A61K 47/48 (2006.01) C07K 14/33 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2365914
The present invention provides for immunogenic compositions and their methods of use as vaccines and their method of preparation. These immunogenic compositions comprise a recombinant protein of toxin A of Clostridium difficile conjugated to a polysaccharide of a microbial pathogen. The immunogenic compositions may include only a truncated portion of toxin A, particularly the repeating units (rARU), that is conjugated to a microbial pathogen polysaccharide. Such compositions are effective in eliciting T-cell dependent and antibody responses. These compositions are therefore effective as vaccines for humans, particularly children, and animals in affording protection against one or more microbial pathogens.
La présente invention concerne des compositions immunogènes, leurs procédés d'utilisation comme vaccins et leurs procédés de préparation. Ces compositions immunogènes contiennent une protéine recombinante de la toxine A de Clostridium difficile, conjuguée à un polysaccharide d'un pathogène microbien. Les compositions immunogènes peuvent contenir uniquement une partie tronquée de la toxine A, en particulier les unités récurrentes (rARU), conjuguée à un polysaccharide de pathogène microbien. De telles compositions sont efficaces pour induire une réponse dépendant des lymphocytes T ou anticorps. Ces compositions sont par conséquent efficaces en tant que vaccins destinés à l'homme, en particulier à l'enfant, et aux animaux, contre un ou plusieurs pathogènes microbiens.
Lyerly David M.
Moncrief J. Scott
Pavliakova Danka
Robbins John B.
Schneerson Rachel
Department Of Health And Human Services
Fetherstonhaugh & Co.
Techlab Inc.
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