Recombinant cmv neutralizing proteins

Details Recombinant cmv neutralizing proteins Recombinant cmv neutralizing proteins

C - Chemistry, Metallurgy

12

N

530/13, 167/130,

C12N 15/38 (2006.01) A61K 39/245 (2006.01) C07K 14/045 (2006.01) C07K 16/08 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1340832

The present invention provides recombinant polypeptides derived from CMV glycoprotein gB and truncated fragments thereof which contain at least one epitope which is immunologically identifiable with one encoded by the CMV genome. The complete characterization of the gB protein, including the identity of glycoprotein gp55, permits the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. This invention provides recombinant polypeptides and recombinant polynucleotides encoding these polypeptides wherein a neutralizing epitope of gB is localized within gp55.

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