Recombinant constructs encoding t cell receptors specific...

Details Recombinant constructs encoding t cell receptors specific... Recombinant constructs encoding t cell receptors specific...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/14 (2006.01) C07K 14/725 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) G01N 33/566 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2246333

Methods are described to obtain nucleic acid molecules that encode T cell receptors and their derivatives that are human HLA-resctricted and which are specific for tumor-associated antigens found in human tumors. These nucleic acids are useful in preparing recombinant cells for diagnosis and therapy of human tumors.

Procédés permettant d'obtenir des molécules d'acides nucléiques codant pour les récepteurs de lymphocytes T et leurs dérivés limités par HLA humains, et spécifiques des antigènes associés à des tumeurs du corps humain. Ces acides nucléiques sont utiles pour la préparation de cellules recombinantes servant au diagnostic et à la thérapie de certaines tumeurs humaines.

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