Recombinant dna and expression vector

C - Chemistry – Metallurgy – 12 – N

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195/1.14, 195/1.

C12N 15/70 (2006.01) C12N 9/78 (2006.01) C12N 15/66 (2006.01)

Patent

CA 2015046

The recombinant DNA according to the present invention contains a regulator region which is at least 50 % homologous to the sections -969 to -991 base pairs and/or -1308 to -1330 base pairs of the sequence in Fig. and in the 3' direction from the regulation sequence contains at least one promoter region which in turn contains a -35/-10 promoter sequence. An expression vector according to the present invention contains a recombinant DNA according to the present invention ligated into a suitable vector molecule. To prepare the recombinant DNA according to the present invention, the pfl gene with its upstream regions is isolated from the gene bank of a microorganism, the desired parts are obtained according to well-known methods and they are combined with the other desired sequences or promoters. When using a recombinant DNA according to the present invention or an expression vector according to the present invention for the inducible and the repressible expression of a foreign gene, the induction is effected under anaerobic conditions and by pyruvate and the repression is effected by oxygen.

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