Recombinant dna encoding the major allergen of plantago...

Details Recombinant dna encoding the major allergen of plantago... Recombinant dna encoding the major allergen of plantago...

C - Chemistry, Metallurgy

12

N

C12N 15/29 (2006.01) A61K 39/36 (2006.01) C07K 14/415 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2449127

A nucleic acid molecule encoding a peptide or protein comprising at least one epitope of the major allergen of Plantago lanceolata, Pla l 1, wherein the nucleic acid molecule a) has the sequence of SEQ ID NO.: 3, b) is a fragment of the sequence SEQ ID NO.: 3, c) has a sequence encoding the amino acid sequence of SEQ ID NO.: 4 or a fragment thereof, d) has a sequence hybridising to SEQ ID NO.: 3 under stringent conditions, e) has a sequence derivable by degeneration of SEQ ID NO.: 3, or f) a complementary strand of any of the sequences a)-e).

L'invention concerne une molécule d'acide nucléique qui code un peptide ou une protéine comprenant au moins un épitope du principal allergène de Plantago lanceolata (Pla l 1). La molécule d'acide nucléique: a) présente la séquence SEQ ID NO.: 3; b) est un fragment de la séquence SEQ ID NO.: 3; c) présente une séquence codant la séquence d'acides aminés SEQ ID NO.: 4 ou un fragment de cette séquence; d) présente une séquence hybridant la séquence SEQ ID NO.: 3 dans des conditions strictes; e) présente une séquence dérivable par dégénérescence de SEQ ID NO.: 3; ou f) présente un brin complémentaire de l'une quelconque des séquences a) à e).

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