Recombinant dna product and methods

Details Recombinant dna product and methods Recombinant dna product and methods

C - Chemistry, Metallurgy

12

N

167/139, 195/1.3

C12N 15/13 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1340879

An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced by site-directed mutagenesis using long oligonucleotides.

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