C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.14, 195/1.
C12N 15/70 (2006.01) C07K 14/02 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1287311
- 1 - Abstract of the Disclosure: The invention provides a recombinant DNA comprising a Hepatitis B virus gene recombined with a vector consisting essentially of a replication origin of SV40 DNA inserted into Escherichia coli plasmid and being preferably deficient in a region of inhibiting replication in mammalian cells. The invention also provides mammalian cells transformed with the recombinant DNA, and a method of production of Hepatitis B virus proteins, i.e. HBsAg and/or HBeAg. These HBV proteins have the same immunological properties as those of the natural HBV proteins originating from human blood plasma and can be used fox the preparation of HBV vaccine and diagnostic reagents.
434868
Hamada Fukusaburo
Matsubara Kenichi
Miyanohara Atsushi
Nozaki Chikateru
Ohtomo Nobuya
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
LandOfFree
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