C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/145 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 14/21 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01) C12N 15/44 (2006.01) C12N 15/49 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2081952
1911H/2090a 18576 TITLE OF THE INVENTION RECOMBINANT DNA SEQUENCES AND PLASMIDS FOR CELLULAR IMMUNITY VACCINES FROM BACTERIAL TOXIN-ANTIGEN CONJUGATES, AND METHODS OF THEIR USE ABSTRACT OF THE INVENTION Recombinant DNA sequences coding for hybrid proteins having two primary components. The first component is a modified bacterial toxin that has translocating ability, while the second component is a polypeptide or protein that is exogenous to an antigen-presenting cell. The hybrid has the ability to be internalized by an antigen-presenting cell, where the hybrid is seubsequently processed and an antigenic segment of the hybrid presented on the surface of the antigen-presenting cell, where the segment elicits an immune response by cytotoxic T lymphocytes.
Donnelly John J.
Friedman Arthur
Hawe Linda A.
Liu Margaret A.
Marshall Mark S.
Donnelly John J.
Friedman Arthur
Gowling Lafleur Henderson Llp
Hawe Linda A.
Liu Margaret A.
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