Recombinant double-stranded rna phages and uses thereof

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 39/12 (2006.01)

Patent

CA 2536254

The present invention provides recombinant double stranded RNA phages (rdsRP) that express dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phages are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Methods are provided to deliver a recombinant dsRNA phage to eukaryotic cells and tissues, either by direct administration, formulated in lipid or polylactide~coglycolide, or by utilizing a bacterial vaccine vector.

La présente invention concerne des phages à ARN à double brin de recombinaison qui expriment des gènes codés par l'ARN à double brin dans des cellules eucaryotes. Des phages à ARN à double brin de recombinaison sont utilisés pour l'expression de cassettes d'expression d'ARN à double brin codant des gènes passagers tels que des antigènes vaccinaux, des protéines bioactives, des protéines immunorégulatoires, des ARN antisens et des ARN catalytiques dans des cellules eucaryotes ou des tissus. Cette invention concerne également des méthodes visant à administrer un phage à ARN à double brin de recombinaison dans des cellules eucaryotes et des tissus, soit par administration directe, inclus dans un lipide ou un polylactide-coglycolide, soit à l'aide d'un vecteur vaccinal bactérien.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Recombinant double-stranded rna phages and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant double-stranded rna phages and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant double-stranded rna phages and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1719360

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.