Recombinant e-selectin made in insect cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2600690

The inventive features include recombinant mammalian E-selectin peptides, nucleic acids encoding said peptides, vectors and cells having these nucleic acids, and methods of making the peptides. Further inventive features include methods of treating diseases and conditions associated with inflammation using recombinant mammalian E-selectin peptides to induce mucosal tolerance to E- selectin.

L'invention concerne des peptides de E-sélectine de recombinaison de mammifère, des acides nucléiques codant pour lesdits peptides, des vecteurs et des cellules comprenant les acides nucléiques ainsi que des procédés de production de ces peptides. L'invention concerne également des méthodes permettant de traiter des maladies et des états associés à une inflammation à l'aide de peptides de E-sélectine de recombinaison de mammifère afin d'induire une tolérance mucosale à la E-sélectine.

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