C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 9/66 (2006.01) A61K 31/70 (2006.01) A61K 38/12 (2006.01) A61K 38/22 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 14/605 (2006.01) C07K 14/61 (2006.01) C07K 14/62 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/17 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2246431
The present invention provides methods for production of heterologous polypeptides, for example amylin, using recombinantly engineered cell lines. Also described are methods engineering cells for high level expression, methods of large scale heterologous protein production, methods for treatment of disease in vivo using viral delivery systems and recombinant cell lines, and methods for isolating novel amylin receptors.
La présente invention se rapporte à des procédés de production de polypeptides hétérologues tels que l'amyline, à l'aide de lignées cellulaires obtenues par génie génétique. L'invention se rapporte également à des procédés de manipulation de cellules pour obtenir un haut niveau d'expression, à des procédés de production à grande échelle de protéines hétérologues, à des procédés de traitement de maladies in vivo à l'aide de systèmes d'administration viraux et de lignée cellulaires de recombinaison, et à des procédés destinés à isoler de nouveaux récepteurs de l'amyline.
Clark Samuel A.
Halban Philippe A.
Kruse Fred
Mcgarry Dennis
Newgard Christopher B.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Betagene Inc.
Board Of Regents The University Of Texas System
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