A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01) A61K 35/16 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2547569
The present invention relates to recombinant factor VIII having a specific activity that is higher than that of the corresponding wild-type factor VIII. The present invention also relates to methods of making and using the recombinant factor VIII. The present invention also relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule.
L'invention concerne un facteur VIII recombiné présentant une activité spécifique qui est plus élevée que celle du facteur VIII de type sauvage correspondant. L'invention concerne également des procédés de fabrication et d'utilisation du facteur VIII recombiné. L'invention concerne également une molécule d'acide nucléique isolée qui code le facteur VIII recombiné, ainsi que des systèmes d'expression d'ADN et des cellules hôtes contenant ladite molécule d'acide nucléique isolée.
Fay Philip J.
Wakabayashi Hironao
Gowling Lafleur Henderson Llp
University Of Rochester
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