C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/36 (2006.01) C07K 14/75 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2730030
The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.
La présente invention porte sur des séquences nucléotidiques codant pour une chaîne alpha, bêta ou gamma de fibrinogène. Les séquences sont optimisées pour l'expression dans un système de culture de cellules eucaryotes. De telles séquences nucléotidiques optimisées permettent l'expression efficace de fibrinogène recombiné et de variants correspondants sous forme intacte, dans un système de culture de cellules eucaryotes.
Bout Abraham
Grimbergen Joseph
Koopman Jacob
Oyen Wiggs Green & Mutala Llp
Profibrix Bv
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