C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/129, 530/15.
C12N 15/62 (2006.01) A61K 39/112 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61K 39/385 (2006.01) C07K 14/02 (2006.01) C07K 14/14 (2006.01) C07K 14/24 (2006.01) C07K 14/255 (2006.01) C07K 14/445 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1340817
The present invention is directed to recombinant genes and their encoded proteins which are recombinant flagellin fusion proteins. Such fusion proteins comprise amino acid sequences specifying an epitope encoded by a flagellin structural gene and an epitope of a heterologous organism which is immunogenic upon introduction of the fusion protein into a vertebrate host. The recombinant genes and proteins of the present invention can be used in vaccine formulations, to provide protection against infection by the heterologous organism, or to provide protection against conditions or disorders caused by an antigen of the organism. In a specific embodiment, attenuated invasive bacteria expressing the recombinant flagellin genes of the invention can be used in live vaccine formulations. The invention is illustrated by way of examples in which epitopes of malaria circumsporozoite antigens, the B subunit of Cholera toxin, surface and presurface antigens of Hepatitis B, VP7 polypeptide or rotavirus, envelope glycoprotein of HIV, and M protein of Streptococcus, are expressed in recombinant flagellin fusion proteins which assemble into functional flagella, and which provoke an immune response directed against the heterologous epitope, in a vertebrate host.
598847
Majarian William Robert
Newton Salete Maria Cardozo
Stocker Bruce Arnold Dunbar
American Cyanamid Company
Majarian William Robert
Newton Salete Maria Cardozo
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Stocker Bruce Arnold Dunbar
LandOfFree
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