Recombinant flu vaccines

Details Recombinant flu vaccines Recombinant flu vaccines

A - Human Necessities

61

K

A61K 39/145 (2006.01)

Patent

CA 2615658

The present invention provides compositions for use as vaccines against the influenza virus, and rapid methods of producing such compositions. The composition include i) at least one peptide derived from an influenza virus, wherein the peptide is fused to a capsid protein derived from a plant virus forming a recombinant capsid fusion peptide and ii) at least one isolated antigenic protein or protein fragment derived from a human or avian influenza virus. The isolated antigenic protein or protein fragment derived from the human or avian influenza virus can be conjugated to the surface of the recombinant capsid fusion peptide.

La présente invention concerne des compositions à utiliser comme vaccins contre le virus grippal, et des procédés rapides de production de telles compositions. Cette composition contient i) au moins un peptide dérivé du virus grippal, ce peptide étant fixé à une protéine de capside dérivée d'un virus de plante formant un peptide de fusion de capside recombinant et ii) au moins une protéine antigénique isolée ou un fragment protéique dérivé(e) d'un virus de grippe humaine ou aviaire. La protéine antigénique isolée ou le fragment protéique dérivé(e) du virus de la grippe humaine ou aviaire peut être conjugué à la surface du peptide de fusion de capside recombinant.

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