Recombinant fowlpox virus

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 39/00 (2006.01) A61K 39/295 (2006.01) C07K 14/065 (2006.01) C12N 5/10 (2006.01) C12N 15/863 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2485655

The invention relates to a recombinant fowlpox virus (FWPV) and a DNA vector containing gene sequences for one such recombinant fowlpox virus. The invention also relates to a pharmaceutical composition containing said recombinant fowlpox virus or a DNA vector, to the use of said recombinant fowlpox virus for treating infectious diseases or tumour diseases, and to a method for producing said recombinant fowlpox virus or DNA vector. The invention further relates to eukaryote cells or prokaryote cells containing the recombinant DNA vector or the recombinant fowlpox virus. The invention is based on the identification of the FWPV-F11L gene as a novel insertion site for foreign DNA.

L'invention concerne un virus de variole aviaire recombinant (FWPV) et un vecteur ADN contenant des séquences géniques pour un tel virus de variole aviaire recombinant. La présente invention porte également sur une préparation pharmaceutique comprenant ce virus de variole aviaire recombinant ou un vecteur ADN, l'utilisation de ce virus de variole aviaire recombinant pour traiter des maladies associées à des infections ou à des tumeurs, ainsi qu'un procédé pour réaliser ce virus de variole aviaire recombinant ou ce vecteur ADN. Enfin, cette invention concerne des eucaryotes ou des procaryotes comprenant le vecteur ADN recombinant ou le virus de variole aviaire recombinant. Ladite invention est basée sur l'identification des gènes FWPV-F11L en tant que nouvel emplacement d'insertion pour l'ADN étranger.

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