Recombinant fusion proteins

Details Recombinant fusion proteins Recombinant fusion proteins

C - Chemistry, Metallurgy

12

N

195/1.22, 195/12

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/585 (2006.01) C07K 14/805 (2006.01) C12N 9/10 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340381

This invention provides a DNA sequence coding for a cleavage site which is specifically cleaved by blood coagulation Factor Xa, a vector containing such a sequence, and a host organism transformed with such a vector. Preferably, in the vector, the Factor Xa cleavage site coding sequence is fused at one end to a product and at its other end to an ATG codon or a sequence coding for at least part of a host protein. This invention also provides a process, for the production of a desired protein or peptide product in native form, comprising: transforming a host organism with a vector as described above; expressing the desired protein or peptide product as a fusion protein comprising the desired protein or peptide product fused to a Factor Xa cleavage site; and cleaving the fusion protein with Factor Xa to yield the foreign gene product in native form.

481611

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