A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 36/074 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) C07K 14/375 (2006.01)
Patent
CA 2711207
The present invention relates to medical uses of a recombinant Ganoderma Lucidum Immunoregulatory Protein (rLZ-8) for anti-tumor, increase of the number of leucocyte and inhibiting immunological rejection, etc. The protein gene sequence was originated from Ganoderma Lucidum and redesigned such that it was more suitable for recombinant expression by eukaryote expression system of Pichia pastoris. Crystal structure (tertiary and quaternary structures) of rLZ-8 was obtained by X-ray diffraction, analysis was performed based on the combination of said crystal structure and relevant functions thereof, a conclusion was drawn that any protein molecule having said structure has the foresaid medical uses, this has already been verified by large number of in vivo and in vitro pharmacodynamic studies. In conclusion, the recom-binant Ganoderma Lucidum Immunoregulatory Protein (rLZ-8) of the present invention can be used as an anti-tumor drug or a increase of the number of leukocyte drug or an immunoinhibitor.
L'invention concerne une protéine immunomodulatrice recombinante de reishi (ganoderma lucidium) (rlz-8) utilisée dans l'élaboration d'un médicament antitumoral. Cette protéine sert à augmenter le nombre de leucocytes et à inhiber un rejet immunologique. L'invention concerne également une composition pharmaceutique comprenant une protéine rlz-8 qui est exprimée à partir de levure pichia.
Sun Fei
Zhang Xitian
Borden Ladner Gervais Llp
Zhang Xitian
LandOfFree
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