Recombinant hcv e2 glycoprotein

Details Recombinant hcv e2 glycoprotein Recombinant hcv e2 glycoprotein

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) A61K 35/76 (2006.01) A61K 38/02 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) A61P 31/14 (2006.01) C07K 1/36 (2006.01) C07K 16/08 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2661814

The invention provides modified hepatitis C virus (HCV) E2 glycoproteins comprising the HCV-E2 receptor-binding domain (RBD) including the HVR1, HVR2 and igVR variable regions wherein in at least one of said variable regions at least a part of the variable region is replaced with a flexible linker sequence. The invention also provides vaccine compositions comprising the modified glycoproteins as well as methods of use thereof.

La présente invention concerne des glycoprotéines E2 du virus de l'hépatite C (Hepatitis C Virus : HCV) modifiées, comprenant le domaine de liaison au récepteur (Receptor-Binding Domain : RBD) HCV-E2 qui inclut les régions variables HVR1, HVR2 et igVR, au moins une partie d'au moins une desdites régions variables étant remplacée par une séquence de liaison flexible. L'invention concerne également des compositions vaccinales comprenant les glycoprotéines modifiées ainsi que leurs procédés d'utilisation.

Affiliated with

Also associated with

Rating

Recombinant hcv e2 glycoprotein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant hcv e2 glycoprotein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant hcv e2 glycoprotein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1402260