C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 1/22 (2006.01) C07K 14/475 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/18 (2006.01) C12P 21/06 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2217020
Disclosed are generation of versatile recombinant heregulins and some of the biological functions and intracellular signaling pathways that these proteins trigger following receptor activation. Also disclosed is the cloning of the cDNA fragments encoding the EGF-like domain of HRG-.alpha., -.beta.2 or - .beta.3 into an eukaryotic expression vector and the transfection of the vector into mammalian cells. The recombinant heregulins are useful in activating the HER4 receptor.
L'invention porte sur la production d'hérégulines de recombinaison polyvalentes ainsi que sur quelques fonctions biologiques et voies de signalisation intracellulaires déclenchées par ces protéines à la suite de l'activation d'un récepteur. L'invention a également trait au clonage de fragments d'ADN complémentaire codant le domaine du type EGF de l'héréguline-.alpha., .beta.2 ou .beta.3 dans un vecteur d'expression eucaryote et à la transfection de ce vecteur dans des cellules mammaliennes. Ces hérégulines de recombinaison s'avèrent utiles dans le cadre de l'activation du récepteur HER4.
Aruffo Alejandro A.
Carlton Gary W.
Culouscou Jean-Michel
Bristol-Myers Squibb Company
Osler Hoskin & Harcourt Llp
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