Recombinant herpes simplex viruses vaccines and methods

Details Recombinant herpes simplex viruses vaccines and methods Recombinant herpes simplex viruses vaccines and methods

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/245 (2006.01) C07K 14/035 (2006.01) C12N 15/869 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2072627

A virus is disclosed which is rendered avirulent by prevention of expression of an active product of a gene which is designated as.gamma. 1 34.5, which maps in the inverted repeats flanking the long unique sequence of herpes simplex virus DNA, and which is not essential for viral growth in cell culture. Viruses from which the gene was deleted or which carried stop codons are totally avirulent on intracerebral inoculation of mice.

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