C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/00 (2006.01) A61K 39/245 (2006.01) A61K 39/295 (2006.01) C07K 14/125 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2196416
The present invention provides a recombinant herpes virus which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant herpes virus which incorporates in exogenous gene expression cassette in which a virus-derived gB gene (a gene homologous to herpes simplex virus gB gene) promoter is used as a promoter for expression of an exogenous gene.
Cette invention concerne un Herpesvirus recombiné capable d'exprimer de manière efficace une protéine étrangère cible chez un animal hôte dans lequel elle a été inoculée, et d'avoir un excellent effet immunologique. Cet Herpesvirus recombiné comporte, intégrée en lui, une cassette d'expression d'un gène étranger. Cette invention fait appel à un promoteur de gène gB originaire d'Herpesvirus (un gène homologue au gène gB du virus Herpes simplex) qui est employé en tant que promoteur de l'expression du gène étranger.
Hamada Fukusaburo
Matsuo Kazuo
Sakaguchi Masashi
Sonoda Kengo
Juridical Foundation The Chemo-Sero-Therapeutic Research Institu
Kirby Eades Gale Baker
LandOfFree
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