Recombinant human alpha-fetoprotein and uses thereof

Details Recombinant human alpha-fetoprotein and uses thereof Recombinant human alpha-fetoprotein and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) C12N 5/02 (2006.01) C12P 21/02 (2006.01) G01N 33/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211324

In general, disclosed are methods of inhibiting autoreactive immune cell proliferation in a mammal, involving administering to the mammal a therapeutically effective amount of recombinant human alpha-fetoprotein or an immune cell anti-proliferative fragment or analog thereof; methods of inhibiting a neoplasm in a mammal, involving administering to the mammal a therapeutically effective amount of recombinant human alpha-fetoprotein or an anti-neoplasm fragment or analog thereof; and methods of cell culture, involving the use of a media containing human alpha-fetoprotein or a fragment or analog thereof.

De façon générale, on divulgue des méthodes pour inhiber la prolifération des cellules immunitaires autoréactives chez un mammifère, comportant l'administration au mammifère d'une quantité thérapeutiquement efficace d'une alpha-foetoprotéine humaine recombinante ou d'un fragment anti-prolifération des cellules immunitaires ou d'un analogue de cette dernière; des méthodes pour inhiber un néoplasme chez un mammifère, comportant l'administration au mammifère d'une quantité thérapeutiquement efficace d'une alpha-foetoprotéine humaine recombinante ou d'un fragment anti-néoplasme ou d'un analogue de cette dernière; ainsi que des méthodes de culture cellulaire, comportant l'utilisation d'un milieu contenant de l'alpha-foetoprotéine humaine ou un fragment ou un analogue de cette dernière.

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