Recombinant human anti-cd18 antibodies

Details Recombinant human anti-cd18 antibodies Recombinant human anti-cd18 antibodies

C - Chemistry, Metallurgy

12

N

530/13, 167/139,

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2034593

JLT 3IBY 18074IBY TITLE OF THE INVENTION RECOMBINANT HUMAN ANTI-CD18 ANTIBODIES ABSTRACT OF THE DISCLOSURE Recombinant immunoglobulin specifically reactive with the CD18 integrin or antigen of leukocytes and methods for the production of the immunoglobulin are disclosed. DNA constructs containing the complementarity determining regions (CDRs) of a murine antibody are recombinantly combined with the chosen frameworks of variable regions of both heavy and light chains of a human antibody. The constructs are transfected into eucaryotic host cells capable of expressing the recombinant immunoglobulin sequence.

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