Recombinant human cytomegalovirus containing foreign gene...

Details Recombinant human cytomegalovirus containing foreign gene... Recombinant human cytomegalovirus containing foreign gene...

C - Chemistry, Metallurgy

12

N

167/129, 167/130

C12N 15/86 (2006.01) A61K 39/015 (2006.01) A61K 39/245 (2006.01) C07K 14/16 (2006.01) C12N 7/01 (2006.01) C12N 7/08 (2006.01) C12N 15/11 (2006.01) C12N 15/869 (2006.01) A61K 48/00 (2006.01)

Patent

CA 1327171

RECOMBINANT HUMAN CYTOMEGALOVIRUS CONTAINING FOREIGN GENE AND USE THEREOF ABSTRACT OF THE DISCLOSURE The present invention provides a virus comprising a DNA sequence essential for replication of a human cytomegalovirus and at least one foreign DNA sequence adapted for expression in a host. The foreign DNA sequence may encode a human immunodeficiency virus anti-sense mRNA sequence or an antigenic polypeptide, e.g., a malarial surface antigen. Also provided are therapeutic compositions and vaccines which comprise the novel viruses of the present invention.

570392

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