C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) C07K 14/755 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01)
Patent
CA 2081659
A DNA sequence coding for a biologically active recombinant human factor VIII derivative, comprising a first DNA seg- ment coding for the 90 kDa chain of human factor VIII and a second DNA segment coding for the 80 kDa chain of human fac- tor VIII, said segments being interconnected by a linker DNA segment coding for a linker peptide of 2 to 10 amino acid residues selected from lysine and arginine; recombinant expression vector comprising such DNA sequence; host cells of animal origin transformed with such recombinant expression vector; a process for the manufacture of recombinant human factor VIII deriva- tive; and human factor VIII derivative containing the heavy chain and the light chain linked by metal ion bon.
Almstedt Annelie B.
Gray (hellstrom) Eva M.
Lind Peter
Ljung Catherine
Sandberg Helena I.
Biovitrum Ab
Fetherstonhaugh & Co.
Kabi Pharmacia Ab
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