C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/20 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01) C07K 16/10 (2006.01) C07K 16/12 (2006.01) C07K 16/44 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2278344
Disclosed are compositions and methods of use that comprise engineered IgA antibodies that, when administered to a host are secreted across the epithelium into the mucosal barriers of the body providing external passive immunotherapy against agents such as viral, bacterial and eukaryotic pathogens. Also disclosed are mini antibodies comprising the minimal transcytosis domains.
L'invention concerne des compositions et des méthodes d'utilisation faisant appel à des anticorps IgA mis au point qui, lorsqu'ils sont administrés à un hôte, sont sécrétés à travers l'épithélium dans les barrières des muqueuses du corps, garantissant ainsi une immunothérapie passive extérieure contre des pathogènes tels que des agents viraux, bactériens et eucaryotes. L'invention concerne également des mini-anticorps comprenant les domaines de transcytose minimaux.
Capra J. Donald
Carayannopoulos Leon N.
Hexham Jonathan M.
Max Edward E.
Bereskin & Parr
The Board Of Regents Of The University Of Texas System
United States Of America Represented By The Secretary Of The Department Of Health And Hum
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