Recombinant human interleukin 6 with homogeneous n-terminus...

Details Recombinant human interleukin 6 with homogeneous n-terminus... Recombinant human interleukin 6 with homogeneous n-terminus...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/54 (2006.01) C07K 19/00 (2006.01) C12N 15/24 (2006.01) C12N 15/27 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2113076

- 14 - ABSTRACT Recombinant human interleukin-6 having a homogeneous N-terminus, comprising peptide molecular species whose N- terminal is Val and having sugar chains; and a process for production of recombinant interleukin-6, characterized by culturing animal cells transformed with a DNA coding for a fusion protein comprising human interleukin-6 whose N-terminus is Val and a signal peptide other than the native signal peptide of human interleukin-6, and recovering the interleukin-6 from the resulting culture. According to the present invention, homogeneous recombinant human IL-6 having Val at the N-terminus and modified with sugar chains is provided.

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