Recombinant human t2 rnase and uses thereof

Details Recombinant human t2 rnase and uses thereof Recombinant human t2 rnase and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 31/7088 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) C07K 1/22 (2006.01) C12N 5/00 (2006.01) C12N 9/22 (2006.01) C12N 9/99 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 2582041

The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The methods are effected by administering to the subject a therapeutically effective amount of a RNase6PL ribonuclease or close homologues thereof.

L'invention concerne le clonage et l'expression hétérologue de RNase6PL T2. L'invention concerne également des méthodes permettant de prévenir, d'inhiber et/ou d'inverser la migration cellulaire, l'assemblage ou le désassemblage des filaments d'actine, la prolifération, la colonisation, la différenciation, l'accumulation et/ou le développement de cellules anormales chez un sujet. Lesdites méthodes sont mises en oeuvre par administration au sujet d'une quantité thérapeutiquement efficace d'une ribonucléase RNase6PL ou d'homologues proches de cette dernière.

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