Recombinant humanized anti-cytomegalovirus antibodies

Details Recombinant humanized anti-cytomegalovirus antibodies Recombinant humanized anti-cytomegalovirus antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/42 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 16/08 (2006.01) C07K 16/46 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146855

A humanised monoclonal antibody, or antigen-binding fragment thereof, which binds to the gH glycoprotein of HCMV, and has HCMV-neutralising activity. Its CDRs are derived from a non-human antibody and its FRs are derived from a human antibody. Certain amino acids of the human FRs have been altered to improve the HCMV-specificity and/or affinity of the antib ody.

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