Recombinant humanized anti-human immunodeficiency virus...

Details Recombinant humanized anti-human immunodeficiency virus... Recombinant humanized anti-human immunodeficiency virus...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/42 (2006.01) C07K 16/10 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170034

The present invention provides human monoclonal antibodies, derived from the murine mAb NM-01 (PCT/US92/07111), which are specifically reactive with HIV gp120 and have the capacity to neutralise the infection of H9 cells in culture by live HIV-1 strains MN and III B as shown by reverse transcriptase, p24 and syncytium formation assays. These antibodies were shown to be as or more effective than the parent murine antibody by the aforementioned criteria.

L'invention se rapporte à des anticorps monoclonaux humains, qui sont dérivés de l'anticorps monoclonal murin NM-01 (PCT/US92/07111) et qui réagissent spécifiquement avec la glycoprotéine gp120 du virus de l'immunodéficience humaine (VIH) et ont le pouvoir de neutraliser l'infection de cellules H9 en culture par les souches MN et IIIB du VIH-1, tel que le montrent les dosages de formation de transcriptase inverse, de p24 et de syncytium. Ces anticorps se sont révélés autant efficaces voire plus efficaces que l'anticorps murin parent selon les critères mentionnés ci-dessus.

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