C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/35 (2006.01) A61P 37/08 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/66 (2006.01) C12P 21/02 (2006.01) G01N 23/20 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441476
Disclosed are recombinant hybrid proteins having at least one antigenic peptide sequence introduced into a scaffold protein that retain a native conformation. Also disclosed are recombinant nucleic acids and vectors encoding the hybrid proteins. The hybrid proteins retain immunogenicity but exhibit reduced allergenicity. The hybrid proteins are therefore particulary useful for therapeutic treatment of allergy.
L'invention concerne des protéines hybrides recombinées comprenant au moins une séquence peptidique antigénique introduite dans une protéine de support qui conserve sa conformation native. L'invention concerne également des acides nucléiques et des vecteurs recombinés codant pour ces protéines hybrides. Ces protéines hybrides conservent leur immunogénicité mais présentent une allergénicité réduite, ce qui les rend particulièrement utiles pour le traitement thérapeutique des allergies.
King Te Piao
Spangfort Michael Dho
Alk-Abello A/s
Robic
The Rockefeller University
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