Recombinant immunogenic actinomycetale

Details Recombinant immunogenic actinomycetale Recombinant immunogenic actinomycetale

C - Chemistry, Metallurgy

12

N

C12N 15/74 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) C07K 14/16 (2006.01) C12N 1/21 (2006.01) C12N 15/49 (2006.01) C12N 15/76 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2111456

2111456 9222658 PCTABS00018 A mycobacteria transformed with an antigen-encoding gene, such as nef, under the control of a Streptomyces stress-responsive promoter, such as the S. albus groES/groEL1 promoter, and preferably associated with a synthetic ribosome binding site. The recombinant mycobacteria can be used as a vaccine against, for example, a pathogen which carries the antigen.

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