C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/21 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2508519
Immunotoxins are disclosed that include a toxin, a variable region of a heavy chain of a monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9, and a variable region of a light chain of the monoclonal antibody that binds the antigen specifically bound by monoclonal antibody 8H9 and effector molecule. These immunotoxins include scFv and dsFv of monoclonal antibody 8H9. The immunotoxins are of use for the treatment of tumors.
L'invention concerne des immunotoxines comprenant: une toxine; une région variable d'une chaîne lourde d'un anticorps monoclonal qui se lie à l'antigène attaché de manière spécifique à l'anticorps monoclonal 8H9; et une région variable d'une chaîne légère d'un anticorps monoclonal qui se lie, d'une part, à l'antigène attaché de manière spécifique à l'anticorps monoclonal 8H9 et, d'autre part, à une molécule effectrice. Ces immunotoxines comprennent les protéines scFv et dsFv de l'anticorps monoclonal 8H9, et peuvent être utilisées dans le traitement de tumeurs.
Cheung Nai-Kong
Onda Masanori
Pastan Ira
Memorial Sloan-Kettering Cancer Center
Smart & Biggar
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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