C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 35/74 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C12N 15/13 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2334745
This invention provides an immunotoxin that specifically binds to and kills cells displaying an HIV gp120 coat protein. The immunotoxin comprises an anti- gp120 antibody directed to the conserved CD4 binding site of gp120 attached to a cytotoxin e.g. a Pseudomonas exotoxin. In one preferred embodiment the immunotoxin is a recombinantly expressed fusion protein comprising a single chain Fv region attached to a modified Pseudomonas exotoxin (3B3(Fv)-PE38).
La présente invention concerne une immunotoxine se liant spécifiquement des cellules qui présentent une protéine d'enrobage gp120 de VIH, cellules qu'elle tue. L'immunotoxine comprend un anticorps anti-gp120 dirigé vers le site de liaison CD4 conservé d'un gp120 fixé à une cytotoxine (par exemple une exotoxine Pseudomonas). Dans un mode de réalisation préféré, l'immunotoxine est une protéine de fusion exprimée par recombinaison comprenant une région de Fv à chaîne unique fixée à une exotoxine Pseudomonas modifiée (3B3(Fv)-PE38).
Barbas Carlos F. III
Bera Tapan K.
Berger Edward A.
Kennedy Paul E.
Pastan Ira H.
Fetherstonhaugh & Co.
The Government Of The United States Represented By The Secretary Of The Department Of Health And Hum
The Scripps Research Institute
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