C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) A01H 5/00 (2006.01) A61K 35/76 (2006.01) A61K 39/145 (2006.01) A61P 31/16 (2006.01) A61P 37/04 (2006.01) C07K 14/11 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/44 (2006.01)
Patent
CA 2707235
A method for synthesizing influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
L'invention concerne une méthode de synthèse de particules pseudovirales (VLP) de la grippe dans une plante ou une partie d'une plante. La méthode implique l'expression de HA de la grippe dans des plantes et la purification par chromatographie d'exclusion stérique. L'invention concerne également une VLP comprenant une protéine HA de la grippe et des lipides de plantes. L'invention concerne en outre un acide nucléique codant pour la protéine HA de la grippe ainsi que des vecteurs. Les VLP peuvent être utilisées pour préparer des vaccins antigrippaux ou peuvent être utilisées pour enrichir des vaccins existants.
Couture Manon
D'aoust Marc-Andre
Dargis Michele
Landry Nathalie
Lavoie Pierre-Olivier
Gowling Lafleur Henderson Llp
Medicago Inc.
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