Recombinant interferon .alpha.2 (if.alpha.2) mutants

Details Recombinant interferon .alpha.2 (if.alpha.2) mutants Recombinant interferon .alpha.2 (if.alpha.2) mutants

A - Human Necessities

61

K

A61K 38/21 (2006.01) C07K 14/57 (2006.01)

Patent

CA 2613737

The present invention provides IFN.alpha.2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN.alpha.2. The present invention further provides pharmaceutical compositions comprising IFN.alpha.2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFN.alpha.2.

La présente invention concerne des mutants IFNa2 et des fragments actifs, des analogues, des dérivés et des variants de ceux-ci qui possèdent une activité agoniste ou antagoniste spécifique améliorée comparée à IFNa2 de type sauvage. Cette invention concerne aussi des compositions pharmaceutiques comprenant des mutants IFNa2 qui conviennent pour traiter ou prévenir le cancer, des maladies auto-immunes, des maladies infectieuses ou des pathologies associées à une expression accrue de IFNa2.

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