Recombinant interleukin-2 hybrid proteins

Details Recombinant interleukin-2 hybrid proteins Recombinant interleukin-2 hybrid proteins

C - Chemistry, Metallurgy

12

N

167/103, 530/13,

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/55 (2006.01) C12N 1/21 (2006.01) C12N 9/24 (2006.01) C12N 9/96 (2006.01) C12N 15/26 (2006.01) C12N 15/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2002854

ABSTRACT Production of recombinant human interleukin-2 (IL-2) fusion proteins can be substantially enhanced by utilizing a vector construction capable of expressing the hybrid protein at high levels. Additionally, the resulting protein can be purified with high yield employing a receptor-affinity column. A further advantage of the present vector construction is that the IL-2 expressed has a more natural sequence than the product provided by prior known expression systems for producing IL-2 hybrid molecules. In a specific embodiment of the invention, a fusion protein of IL-2 and Pseudomonas exotoxin is expressed at high levels in E. coli and purified to homogeneity with excellent recoveries and the desired high biological activity.

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